New mouth rinse from Pearlie White and NDCS launched, developed from research study on SARS-CoV-2 virus

With their new product on display, Associate Professor Jaya Seneviratne (left) and Andy Ong (right), look forward to more opportunities for partnership between public and private stakeholders in fueling healthcare innovation (Image: Dental Asia)

A study from the National Dental Centre Singapore (NDCS) on the efficacy of mouth rinses in reducing the SARS CoV-2 virus during the Covid-19 pandemic has led to the development of an antiseptic mouth rinse with anti-viral properties. The new product is named Pearlie White Defenze Antiseptic Fluoride Mouth Rinse, and was developed by NDCS in partnership with home-grown Singapore oral care brand Pearlie White, highlighting the innovation of public-industry partnerships which brings together medical research with commercial expertise.

Speaking at a media launch for the new mouth rinse on 23 Nov, Associate Professor Jaya Seneviratne, principal investigator, National Dental Research Institute Singapore (NDRIS), shared the inspiration and development of the product.

“Inspiration for this research first originated from my volunteer work at the migrant workers’ dormitory during the height of the pandemic in 2020. I am elated we were able to rapidly progress the study to achieve this unique mouth rinse formulation with the vast industry experience from Pearlie White,” said Prof Jaya.

Prof Jaya first conducted a randomised clinical trial in 2020 to study the efficacy of mouth rinses on reducing the salivary SARS CoV-2, which showed that Cetylpyridinium Chloride (CPC) formulated commercial mouth rinses effectively suppress the salivary SARS-CoV-2 levels within five minutes of use and sustain for up to six hours after use.

Following the results of the study, NDCS partnered with Pearlie White to develop a unique formulation of a topical antiseptic mouth rinse with anti-viral properties. The formulation brings together expertise in oral health research and deep industry knowledge and experience. Prof Jaya and his team will be furthering their study with a clinical trial based on the new formulation. 

“We are proud to announce that this Halal-Certified product is Made In Singapore, and that this landmark public-private partnership has the potential to make a profound impact on improving consumer oral health globally. It is truly a world class home-grown product that all Singaporeans can benefit from and be proud of,” said Andy Ong, managing director, Pearlie White.

The alcohol-free antiseptic formulation contains a combination of anti-viral and plaque fighting ingredients, including CPC, fluoride, xylitol and zinc gluconate. It is also enhanced with natural ingredients such as echinacea, chamomile, cinnamon, honeysuckle, licorice, myrrh, sage, and tea tree oil. It is dermatologically tested and safe for daily use. 

The proprietary formulation of CPC, zinc and xylitol provides the mouth rinse with its enhanced antiviral properties (Image: Pearlie White)

“This is an exciting innovation that holds promise to manage the spread of aerosol transmitted viruses. The mouth rinse will reduce overall cross-infection between patients and healthcare workers and offer benefits in aerosol-generating clinical settings, such as intubation for general anaesthesia. This innovation can further protect dentists and dental providers from risk of infection through aerosols generated during dental treatments,” said Professor Marco A Peres, deputy CEO, research and education, NDCS.

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